The departure of Jay Carney, Amazon’s top public relations and public policy executive, has set off an executive reshuffling that could recalibrate Amazon’s policy priorities at a time when the company faces the most serious regulatory challenges in its 28-year history.

CEO Andy Jassy is on the hunt for a new senior policy executive, he wrote to staff in an email reviewed by The Information. The search will focus on external candidates, according to two former employees in Amazon’s corporate affairs group familiar with the senior leadership team’s thinking. The new executive would set Amazon’s objectives on antitrust, labor and transportation issues following a string of high-profile public policy setbacks, such as the collapse of Amazon’s plans for a second headquarters in New York and a successful unionization drive at an Amazon warehouse in Staten Island. The new executive will not also oversee Amazon’s communications team, as Carney did, the people said.